2-Fluorobenzenesulphonyl chloride
2-fluorobenzenesulfonyl chloride
CAS: 2905-21-7
Molecular Formula: C6H4ClFO2S
2-Fluorobenzenesulphonyl chloride - Names and Identifiers
| Name | 2-fluorobenzenesulfonyl chloride |
| Synonyms | 2-FluoroPhenylsulfonylChloride O-FLUOROBENZENESULFONYL CHLORIDE 2-fluorobenzenesulfonyl chloride 2-FLUOROBENZENESULFONYL CHLORIDE 2-Fluorobenzenesulphonyl chloride 2-FLUOROBENZENESULPHONYL CHLORIDE 2-Fluorobenzene-1-sulfonyl chloride 2-FLUOROBENZENE-1-SULFONYL CHLORIDE BENZENESULFONYL CHLORIDE, 2-FLUORO- dimethyl [2-nitro-4-(trifluoromethyl)phenyl]propanedioate |
| CAS | 2905-21-7 |
| EINECS | 628-227-6 |
| InChI | InChI=1/C12H10F3NO6/c1-21-10(17)9(11(18)22-2)7-4-3-6(12(13,14)15)5-8(7)16(19)20/h3-5,9H,1-2H3 |
2-Fluorobenzenesulphonyl chloride - Physico-chemical Properties
| Molecular Formula | C6H4ClFO2S |
| Molar Mass | 194.61 |
| Density | 1.47 g/mL at 25 °C (lit.) |
| Melting Point | 27-30 °C (lit.) |
| Boling Point | 246-247 °C (lit.) |
| Flash Point | >230°F |
| Vapor Presure | 2.09E-05mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.470 |
| Color | Clear colorless |
| BRN | 2093979 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | Moisture Sensitive |
| Refractive Index | n20/D 1.537(lit.) |
2-Fluorobenzenesulphonyl chloride - Risk and Safety
| Risk Codes | R34 - Causes burns R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3265 8/PG 2 |
| WGK Germany | 3 |
| HS Code | 29049090 |
| Hazard Note | Corrosive |
| Hazard Class | 8 |
| Packing Group | II |
2-Fluorobenzenesulphonyl chloride - Introduction
2-fluorobenzenesulfonyl chloride(2-fluorobenzenesulfonyl chloride) is an organic compound with the chemical formula C6H4ClFO2S. It has a colorless to light yellow liquid and is less volatile at room temperature.
2-fluorobenzenesulfonyl chloride is commonly used as an acid chloride reagent in organic synthesis. It can be used in the synthesis of organic compounds having an acid chloride functional group, such as sulfonyl chloride esters, acid chloride amines, and acid chloride ethers, etc. Since 2-fluorobenzenesulfonyl chloride can undergo nucleophilic substitution reactions in the reaction and is highly reactive to active nucleophiles, it has a wide range of applications in organic synthesis.
The preparation method of 2-fluorobenzenesulfonyl chloride can be obtained by fluorinating O-chlorobenzene and reacting with sulfinyl chloride. First, take the correct amount of O-chlorobenzene and fluorinate it using a fluorinating agent to produce O-fluorobenzene. O-fluorobenzene is then reacted with sulfinyl chloride to give 2-fluorobenzenesulfonyl chloride.
When using 2-fluorobenzensulfonyl chloride, it is necessary to pay attention to its toxicity and irritation. It is a sensitizing substance and has an irritating effect on the eyes and respiratory tract. Appropriate protective equipment such as gloves, goggles and masks must be worn during operation. In addition, it should be used under well-ventilated conditions and avoid contact with strong oxidants, strong bases or active metals to avoid dangerous reactions. Storage should avoid exposure to light, and placed in a sealed container, away from fire and high temperature.
2-fluorobenzenesulfonyl chloride is commonly used as an acid chloride reagent in organic synthesis. It can be used in the synthesis of organic compounds having an acid chloride functional group, such as sulfonyl chloride esters, acid chloride amines, and acid chloride ethers, etc. Since 2-fluorobenzenesulfonyl chloride can undergo nucleophilic substitution reactions in the reaction and is highly reactive to active nucleophiles, it has a wide range of applications in organic synthesis.
The preparation method of 2-fluorobenzenesulfonyl chloride can be obtained by fluorinating O-chlorobenzene and reacting with sulfinyl chloride. First, take the correct amount of O-chlorobenzene and fluorinate it using a fluorinating agent to produce O-fluorobenzene. O-fluorobenzene is then reacted with sulfinyl chloride to give 2-fluorobenzenesulfonyl chloride.
When using 2-fluorobenzensulfonyl chloride, it is necessary to pay attention to its toxicity and irritation. It is a sensitizing substance and has an irritating effect on the eyes and respiratory tract. Appropriate protective equipment such as gloves, goggles and masks must be worn during operation. In addition, it should be used under well-ventilated conditions and avoid contact with strong oxidants, strong bases or active metals to avoid dangerous reactions. Storage should avoid exposure to light, and placed in a sealed container, away from fire and high temperature.
Last Update：2024-04-10 22:29:15
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View History
2-Fluorobenzenesulphonyl chloride
2-乙基呋喃
L-赖氨酸二异氰酸酯 (S)-2,6-二异氰酸基己酸乙酯
2-环己酮基羧酸乙酯
4-甲基-3-戊烯酸
2-甲基噻唑-4-碳硫代酰胺
吗啉脂肪酸盐果蜡
2,4-二甲基吡咯-3-羧酸
2-乙基呋喃
L-赖氨酸二异氰酸酯 (S)-2,6-二异氰酸基己酸乙酯
2-环己酮基羧酸乙酯
4-甲基-3-戊烯酸
2-甲基噻唑-4-碳硫代酰胺
吗啉脂肪酸盐果蜡
2,4-二甲基吡咯-3-羧酸